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ECRG4: a new potential target in precision medicine
Xin Qin, Ping Zhang
Frontiers of Medicine 2019, Volume 13, Issue 5, Pages 540-546 doi: 10.1007/s11684-018-0637-9
Keywords： ECRG4 tumor suppressor gene sentinel molecule precision medicine cell senescence epithelium homeostasis
Linlin LIANG, Bei XU, Guijin ZHU
Frontiers of Medicine 2009, Volume 3, Issue 2, Pages 220-226 doi: 10.1007/s11684-009-0037-2
Keywords： gonadotropin-releasing hormone ovarian reserve embryo developmental ability ovarian surface epithelium
Joseph Cannova,Peter Breslin S.J.,Jiwang Zhang
Frontiers of Medicine 2015, Volume 9, Issue 3, Pages 288-303 doi: 10.1007/s11684-015-0412-0
Toll-like receptors (TLRs), which are found in innate immune cells, are essential mediators of rapid inflammatory responses and appropriate T-cell activation in response to infection and tissue damage. Accumulating evidence suggests that TLR signaling is involved in normal hematopoiesis and specific hematologic pathologies. Particular TLRs and their downstream signaling mediators are expressed not only in terminally differentiated innate immune cells but also in early hematopoietic progenitors. Sterile activation of TLR signaling is required to generate early embryonic hematopoietic progenitor cells. In adult animals, TLR signaling directly or indirectly promotes differentiation of myeloid cells at the expense of that of lymphoid cells and the self-renewal of hematopoietic stem cells during infection and tissue damage. Activating mutations of the MyD88 gene, which codes for a key adaptor involved in TLR signaling, are commonly detected in B-cell lymphomas and other B-cell hematopathologies. Dysregulated TLR signaling contributes to the pathogenesis of many hematopoietic disorders, including bone marrow failure, myelodysplastic syndrome, and acute myeloid leukemia. Complete elucidation of the molecular mechanisms by which TLR signaling mediates the regulation of both normal and pathogenic hematopoiesis will prove valuable to the development of targeted therapies and strategies for improved treatment of hematopoietic disorders.
Keywords： TLR MyD88 hematopoiesis bone marrow failure leukemia myelodysplastic syndrome
Zinc homeostasis in the metabolic syndrome and diabetes
Xiao Miao, Weixia Sun, Yaowen Fu, Lining Miao, Lu Cai
Frontiers of Medicine 2013, Volume 7, Issue 1, Pages 31-52 doi: 10.1007/s11684-013-0251-9
Zinc (Zn) is an essential mineral that is required for various cellular functions. Zn dyshomeostasis always is related to certain disorders such as metabolic syndrome, diabetes and diabetic complications. The associations of Zn with metabolic syndrome, diabetes and diabetic complications, thus, stem from the multiple roles of Zn: (1) a constructive component of many important enzymes or proteins, (2) a requirement for insulin storage and secretion, (3) a direct or indirect antioxidant action, and (4) an insulin-like action. However, whether there is a clear cause-and-effect relationship of Zn with metabolic syndrome, diabetes, or diabetic complications remains unclear. In fact, it is known that Zn deficiency is a common phenomenon in diabetic patients. Chronic low intake of Zn was associated with the increased risk of diabetes and diabetes also impairs Zn metabolism. Theoretically Zn supplementation should prevent the metabolic syndrome, diabetes, and diabetic complications; however, limited available data are not always supportive of the above notion. Therefore, this review has tried to summarize these pieces of available information, possible mechanisms by which Zn prevents the metabolic syndrome, diabetes, and diabetic complications. In the final part, what are the current issues for Zn supplementation were also discussed.
Keywords： zinc zinc transporters metallothionein diabetes diabetic complications insulin resistance antioxidant
Frontiers of Medicine 2021, Volume 15, Issue 3, Pages 460-471 doi: 10.1007/s11684-021-0861-6
Keywords： low-carbohydrate diet obesity nonalcoholic fatty liver disease continuous glucose monitoring mean sensor glucose
Frontiers of Medicine doi: 10.1007/s11684-023-0983-0
Keywords： mitochondrial fission Ca Berberine alleviates myocardial murine model HFpEF
Planetary Homeostasis of Reactive Nitrogen Through Anaerobic Ammonium Oxidation
Guibing Zhu,Bangrui Lan,Shuci Liu,Cameron M. Callbeck,Shanyun Wang,Liping Jiang,Asheesh Kumar Yadav,Jan Vymazal,Mike S. M. Jetten,Ganlin Zhang,Yongguan Zhu,
Engineering doi: 10.1016/j.eng.2023.09.013
Keywords： biogeochemical N-cycle oxic–anoxic interface nature-based solution biogeoengineering nitrogen sustainable development
Emerging roles of podoplanin in vascular development and homeostasis
Yanfang Pan,Lijun Xia
Frontiers of Medicine 2015, Volume 9, Issue 4, Pages 421-430 doi: 10.1007/s11684-015-0424-9
Podoplanin (PDPN) is a mucin-type O-glycoprotein expressed in diverse cell types, such as lymphatic endothelial cells (LECs) in the vascular system and fibroblastic reticular cells (FRCs) in lymph nodes. PDPN on LECs or FRCs activates CLEC-2 in platelets, triggering platelet activation and/or aggregation through downstream signaling events, including activation of Syk kinase. This mechanism is required to initiate and maintain separation of blood and lymphatic vessels and to stabilize high endothelial venule integrity within lymph nodes. In the vascular system, normal expression of PDPN at the LEC surface requires transcriptional activation of Pdpn by Prox1 and modification of PDPN with core 1-derived O-glycans. This review provides a comprehensive overview of the roles of PDPN in vascular development and lymphoid organ maintenance and discusses the mechanisms that regulate PDPN expression related to its function.
Keywords： podoplanin CLEC-2 Prox1 O-glycosylation lymphatic vascular development and maintenance lymphoid organ homeostasis
The relevance of James Lovelock’s research and philosophy to environmental science and academia
Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 3, doi: 10.1007/s11783-023-1639-7
Keywords： independence Climate change Electron capture detector Environmental equilibrium Global warming Homeostasis
An Evaluation Method of Human Gut Microbial Homeostasis by Testing Specific Fecal Microbiota Article
Zhongwen Wu, Xiaxia Pan, Yin Yuan, Pengcheng Lou, Lorina Gordejeva, Shuo Ni, Xiaofei Zhu, Bowen Liu, Lingyun Wu, Lanjuan Li, Bo Li
Engineering 2023, Volume 29, Issue 10, Pages 110-119 doi: 10.1016/j.eng.2023.03.007
Research on microecology has been carried out with broad perspectives in recent decades, which has enabled a better understanding of the gut microbiota and its roles in human health and disease. It is of great significance to routinely acquire the status of the human gut microbiota; however, there is no method to evaluate the gut microbiome through small amounts of fecal microbes. In this study, we found ten predominant groups of gut bacteria that characterized the whole microbiome in the human gut from a largesample Chinese cohort, constructed a real-time quantitative polymerase chain reaction (qPCR) method and developed a set of analytical approaches to detect these ten groups of predominant gut bacterial species with great maneuverability, efficiency, and quantitative features. Reference ranges for the ten predominant gut bacterial groups were established, and we found that the concentration and pairwise ratios of the ten predominant gut bacterial groups varied with age, indicating gut microbial dysbiosis. By comparing the detection results of liver cirrhosis (LC) patients with those of healthy control subjects, differences were then analyzed, and a classification model for the two groups was built by machine learning. Among the six established classification models, the model established by using the random forest algorithm achieved the highest area under the curve (AUC) value and sensitivity for predicting LC. This research enables easy, rapid, stable, and reliable testing and evaluation of the balance of the gut microbiota in the human body, which may contribute to clinical work.
Keywords： Gut microbiota Machine learning Microbial dysbiosis Quantitative polymerase chain reaction Chinese cohort
Title Author Date Type Operation
Effect of repeated gonadotropin stimulation on ovarian reserves and proliferation of ovarian surface epithelium
Linlin LIANG, Bei XU, Guijin ZHU
Journal Article
Toll-like receptor signaling in hematopoietic homeostasis and the pathogenesis of hematologic diseases
Joseph Cannova,Peter Breslin S.J.,Jiwang Zhang
Journal Article
Zinc homeostasis in the metabolic syndrome and diabetes
Xiao Miao, Weixia Sun, Yaowen Fu, Lining Miao, Lu Cai
Journal Article
Low-carbohydrate diets lead to greater weight loss and better glucose homeostasis than exercise: a randomized
Journal Article
alleviates myocardial diastolic dysfunction by modulating Drp1-mediated mitochondrial fission and Ca homeostasis
Journal Article
Planetary Homeostasis of Reactive Nitrogen Through Anaerobic Ammonium Oxidation
Guibing Zhu,Bangrui Lan,Shuci Liu,Cameron M. Callbeck,Shanyun Wang,Liping Jiang,Asheesh Kumar Yadav,Jan Vymazal,Mike S. M. Jetten,Ganlin Zhang,Yongguan Zhu,
Journal Article
Emerging roles of podoplanin in vascular development and homeostasis
Yanfang Pan,Lijun Xia
Journal Article
The relevance of James Lovelock’s research and philosophy to environmental science and academia
Journal Article
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